A Publication of Dickinson College
Volume 81· Number 4 - Spring 2004

Smallpox was eradicated in 1980 but, Weiss says, “Don’t think smallpox is over by a long shot. The threat [of bioterrorists acquiring the virus] is overstated, but it still exists.”

Outbreak Buster

Don Weiss ’79 tries to keep infectious disease at bay for 8 million people

By Sherri Kimmel

Art-deco eagles guard the stone exterior of the sprawling New York Department of Health building on Worth Street, a 10-minute walk from the eerie gap in the lower Manhattan skyline that was once the World Trade Center. Inside, phalanxes of tough-talking guards go about their security details very thoroughly. Bags are screened, IDs checked and photos taken of every visitor. Before heading upstairs you adhere a ghostly image of yourself to your lapel, below which is typed your name and the date of your visit.

The man who recommended all of this vigilance is waiting upstairs—well, not really waiting. He’s pounding out a grant proposal to the Centers for Disease Control. As medical director of the Surveillance Unit of the Communicable Disease Program for the five boroughs of New York, Weiss is a man who doesn’t waste a moment. He directs a staff of 40 medical professionals/sleuths seeking the cause and containment of the disease du jour. An example he mentions features a weird strain of salmonella that originated with some funky chicken served at a wedding reception. Once a lab, doctor or hospital reports an unusual case, Weiss and his staff go on the prowl. They interview the victim, find out where he or she has been and with whom. They interview other wedding guests and find out that those who ate the chicken took sick, while those who stuck with pasta didn’t.

“We want to prevent transmission to other people, so we find out what happened to cause the spread, then recommend and implement control measures,” Weiss explains. “We find out what happened in the production of the chicken Cordon Bleu, working with the bureau of investigation and the restaurant investigators.” In this sample case, investigation reveals that the refrigerator in which the chicken was stored prior to prep had a temperature above the required 40 degrees Fahrenheit. The remedy is the kitchen will be closed until the refrigerator is repaired.

For each investigation, says Weiss, “there are people who do interviews, and we all go over and interpret [findings] together and make decisions. It’s a collaborative effort.”

Depending upon the rarity of the disease, one or dozens of infected people can signify an outbreak.

“A single case of smallpox or the plague is an outbreak in New York City,” notes Weiss. “A couple of Legionnaires cases would be an outbreak. There isn’t a simple, straightforward definition. I’m surprised we don’t have more outbreaks in New York City than we do.”

Frightening diseases, such as SARS and West Nile Virus, also fall under Weiss’s purview. And since 9/11, he’s not only been handling traditional surveillance of diseases that are not deliberately dispersed in the population, but also syndromic surveillance, which covers bioterrorism. “Since 9/11 there has been a big influx of money to public health, under bioterrorism.”

More money isn’t necessarily good for public health, though, if it is concentrated in one area, he says. Containing a disease, such as tuberculosis, and taking it off the front burner also can be bad, because lack of federal and local health-department funding can sideline the vigilance needed to detect and control a disease.

“The better you do your job, the less funding you have to do your job,” Weiss says. Doctors who no longer possess the know-how to diagnose a disease that was thought eradicated also can contribute to its revival.

Weiss came to epidemiology after working in pediatrics, following a decision not to pursue a Ph.D. in chemistry, his major at Dickinson. After earning his M.D. at the New Jersey Medical School, Weiss worked in a mobile health care unit for homeless children around New York City that was co-founded by musician Paul Simon and physician Irving Redlener. Weiss moved to St. Louis in 1993 and earned a master’s in public health while working as a pediatrician and with the public-health department. Four years ago he returned to his home city of New York and his current job with what he calls “the largest public-health department in the world, as far as cities and states go.” (He is one of more than 6,000 employees.) But disease control is not his only interest.

He’s an avid photographer—landscapes in the Ansel Adams mode as well as portraits of children that he saw as a clinician. And, though the only previous writing he’d done was scientific, he is now halfway through a novel about a fictitious Midwestern city where a disease takes hold. When asked if it will be called Outbreak, he shakes his head and says, “Dustin Hoffman already did that movie a couple of years ago.”

Certain that he’ll finish the manuscript but uncertain of its salability, Weiss is content with his day job where he works with “smart, motivated” colleagues and has enough staff to handle an outbreak. Being an epidemiologist has become more hip in the last few years, he says, citing proof:

“You know your career has made it when it gets to be a cartoon in The New Yorker.”

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