Dr. Charles Zwemer
My research interest is in hypothesis testing
in the areas of cardiovascular, respiratory and renal function
in normal and pathological states. My students and I study
various cardiovascular, respiratory and metabolic survival
mechanisms employed by mammals in response to low oxygen/high
carbon dioxide environments and other extreme environments.
I'm a broadly trained comparative physiologist with interests
in respiratory and cardiovascular function. I became a physiologist
because I enjoyed the way the discipline applied fundamentals
of physics, mathematics, engineering, and chemistry to the study
of how animals work. Sitting squarely at the crossroads of biology,
the study of physiology integrates the processes of life by connecting
function at the sub-cellular level with tissue, organ and ultimately
whole animal activity. At the heart of it all though, being a
physiologist beats working for a living.
Life at the Extremes (BIOL 120)
Microanatomy (BIOL 335)
Physiology (BIOL 333)
Vertebrate Biology (BIOL 334)
Postdoctoral Fellow • University of Michigan Medical School, 1995
Focus: Respiration and Cardiovascular Physiology
Advisor: Louis G. D’Alecy, D.M.D., Ph.D.
Ph.D., Indiana University Medical Sciences Program, 1993
Focus: Comparative Physiology
Advisor: Henry D. Prange, Ph.D.
B.A., Hope College, 1987
Advisor: Christopher C. Barney, Ph.D.
Selected Publications (* indicates student co-author)
Zwemer, C.F., Whitesall,
S.E., and L.G. D'Alecy. (1994). Cardiopulmonary-cerebral resuscitation
with 100% oxygen exacerbates neurological dysfunction following nine
minutes of normothermic cardiac arrest in dogs. Resuscitation 27(2):
Zwemer, C.F., O'Connor,* E.M.,
Whitesall, S.E., and L.G. DAlecy. (1997) Gender differences in 24 hour outcome
following resuscitation after nine minutes of cardiac arrest in dogs. Critical
Care Medicine 25 (2): 330-338.
Zwemer, C.F. (1999) Unilateral nephrectomy
in the rat as a teaching model of renal function. American Journal of Physiology
276 (Adv. Physiol. Educ 21):S79-S85,
Zwemer, C.F., Shoemaker, J.L. jr.*,
Davis, R.E.*, Hazard, S.W. III*,
Bartoletti, A.G.*, and C. Phillips.(2000)
Hyperoxic reperfusion exacerbates postischemic renal dysfunction. Surgery 128:815-821.
Zwemer, CF, Song*, M, Carello*, KA, and LG D’Alecy. (2007). Strain
Differences in Response to Acute Hypoxia: CD-1versus C57BL/6J Mice.
The Journal of Applied Physiology 102:286-293.
Song, M*, Zwemer, CF, Whitesall, SE and LG D’Alecy. (2007). NOS
inhibition Increases Acute Hypoxic Tolerance in Mice. The Journal
of Applied Physiology 102: 610-615.
Selected Presentations (* indicates student co-author)
Zwemer, CF, Campbell, S*, Coleman, E*, Ellerman, J*, Levit, R*, Lucin,
K*, and CL Ritchie*. Spring Experimental Biology Meetings, New Orleans,
LA April 20-24, 2002. “Decreased VO2 in response to acute inspired
hypoxia and hypercapnic hypoxia in rabbits (O. Cuniculus).”
Zwemer, CF, O’Malley*, MJ, Powell,* N. Spring Experimental Biology
Meetings, San Diego, CA March 31-April 05, 2005. “12 hour fast significantly
alters resting VO2, VCO2 and RER as measured by indirect calorimetry.”
Strahota MC*, D’Alecy LG, and CF Zwemer. Experimental Biology,
San Diego, CA April 05-09, 2008. “Muscarinic M2 selective antagonism
prolongs 5’-AMP-induced hypometabolism.”
Hazard SW*, Foley TT, Zwemer CF,
Mackay DR, and HP Ehrlich. Plastic Surgery Research Council National
Meeting (2008), Chicago, IL “Topical vanadate increases the breaking
strength of median laparotomy incisions. ”